HealthScience DailyWhy some people escape Alzheimer’s despite carrying a high-risk gene
Researchers have found a rare gene mutation that protects some people from Alzheimer's even when they carry the high-risk APOE gene, pointing to a possible new treatment.
Scientists have discovered why some people with a high genetic risk of Alzheimer’s remain mentally sharp into their 80s, uncovering a rare mutation that protects the brain from harmful protein buildup. The findings reveal a potential new way to prevent early brain damage and could pave the way for treatments that mimic this natural defense.
Columbia University researchers published a study in Nature Aging explaining why some people with the high-risk APOE gene never develop Alzheimer's disease.
A rare mutation in the FN1 gene limits excess fibronectin buildup around brain blood vessels, protecting the blood-brain barrier from damage, the study found.
Scientists say the discovery moves them from a genetic clue to a disease mechanism, opening ideas for treatments that could recreate this natural protection.
The study found the FN1 mutation limits harmful protein buildup around brain blood vessels, and researchers say it could lead to treatments that recreate this natural protection.
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