Scientists discover cells that cheat death and rebuild damaged tissue
Scientists have found that some cells can survive the process of programmed death and then help rebuild damaged tissue, which could aid cancer research.
Scientists discovered a population of cells that can start the process of programmed cell death, survive it, and then help rapidly rebuild damaged tissue. Their descendants become far more resistant to future damage, revealing a mechanism that could improve healing but may also help cancers return after treatment.
Researchers at the Weizmann Institute of Science have identified a molecular mechanism explaining how damaged tissues can dramatically rebuild themselves.
The study, published in Nature Communications, found that caspase enzymes normally linked to cell death can instead help certain cells survive and become more resistant to future injury.
The same survival mechanism may be exploited by cancer cells, the researchers say, potentially contributing to tumours that return in a more aggressive, treatment-resistant form.
The researchers say the discovery could eventually help develop treatments that encourage healthy tissue repair while reducing the risk of cancer returning.
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