Healthmedicalxpress.comEngineered 'triple-threat' immune cells could fight plaque buildup that causes heart attacks and strokes
UCLA scientists have engineered immune cells that attack the fatty plaque buildup in arteries from three angles at once, outperforming earlier single-target approaches in lab tests.
A UCLA research team has engineered a new type of immune cell that attacks atherosclerotic plaques—the fatty buildup inside artery walls that drives most heart attacks and strokes. These engineered cells work by recognizing three harmful cell types within plaques. The paper is published in the journal Circulation Research.
UCLA researchers engineered a new immune cell called FAP.CAR-NKT that targets the arterial plaque buildup responsible for most heart attacks and strokes.
The cells attack three harmful cell types inside plaques simultaneously, outperforming earlier single-target versions in mouse models and human artery tissue.
Atherosclerosis remains hard to treat even with existing drugs, and the study found this triple-threat approach cleared more dangerous plaque cells than previous methods.
This is early-stage research in mice and lab tissue, so ask your GP about existing options if you have cardiovascular risk factors while this work continues.
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