NewsMedical XpressScientists map dormant cancer cells' hideouts, opening new targets for treatment
Scientists have mapped where dormant breast cancer cells hide inside tumours, finding they are shielded by immune cells — a discovery that could lead to better treatments.
Researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and UCL Genetics Institute have created a detailed map of cells within breast tumors and identified distinct neighborhoods of proliferating and dormant cells. The study, published in Genome Medicine, reveals that protective immune and connective cells surround the hibernating cancer cells, potentially shielding them from treatments. It suggests future therapies may need to target not only different cancer cell states but also the local environments that help them survive, to both halt tumor growth and prevent cancer from coming back later.
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